Publications and Preprints

High-confidence and high-throughput quantification of synapse engulfment by oligodendrocyte precursor cells

Jessica A. Kahng, Andre M. Xavier, Austin Ferro, Samantha X. Tang, Yohan S. S. Auguste, Lucas Cheadle. 2024

Nature Protocols

A brain-body feedback loop driving HPA-axis dysfunction in breast cancer

Adrian Gomez, Yue Wu, Chao Zhang, Leah Boyd, Tse-Luen Wee, Joseph Gewolb, Corina Amor, Lucas Cheadle, Jeremy C. Borniger. 2024

Preprint.

A single-cell transcriptomic atlas of sensory-dependent gene expression in developing mouse visual cortex

Andre M. Xavier, Qianyu Lin, Chris J. Kang, Lucas Cheadle. 2024

Preprint.

The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian function in vivo

Austin Ferro, Anosha Arshad, Leah Boyd, Tess Stanley, Adrian Berisha, Uma Vrudhula, Adrian M. Gomez, Jeremy C. Borniger, Lucas Cheadle. 2024

Preprint.

Disruption of Cholinergic Retinal Waves Alters Visual Cortex Development and Function

Timothy J Burbridge, Jacob M Ratliff, Deepanjali Dwivedi, Uma Vrudhula, Francisco Alvarado-Huerta, Lucas Sjulson, Leena Ali Ibrahim, Lucas Cheadle, Gordon Fishell, Renata Batista-Brito. 2024

Preprint.

Emerging roles of oligodendrocyte precursor cells in neural circuit development and remodeling.

Buchanan, J., da Costa, N.M., and Cheadle, L. 2023.

Trends in Neurosciences 46(8):628-639.

Neuron-glia communication through bona fide synapses.

Cheadle, L. 2023.

Nature Reviews Neuroscience 24(7):395.

Integrated high-confidence and high-throughput approaches for quantifying synapse engulfment by oligodendrocyte precursor cells.

Kahng, J.A., Xavier, A.M, Ferro, A., Auguste, Y.S.S., and Cheadle, L. 2023.

Preprint.

Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice.

Auguste*, Y.S.S., Ferro*, A., Kahng, J.A., Xavier, A.M., Dixon, J.R., Vrudhula, U., Nichitiu, A.-S., Rosado, D., Wee, T.-L., Pedmale, U.V., and Cheadle, L. 2022.

Nature Neuroscience 25(10):1273-1278.

When the levee of sympathetic outflow breaks.

Ferro, A., and Cheadle, L. 2022.

Immunity 55(8):1334-1336.

Oligodendrocyte precursor cells engulf synaptic inputs in an experience- and microglia-dependent manner.

Auguste, Y., Ferro, A., Dixon, J., Vrudhula, U., Kahng, J., Nichitiu, A., Cheadle, L. 2022.

Preprint.

Microglia, Cytokines, and Neural Activity: Unexpected Interactions in Brain Development and Function.

Ferro, A., Auguste, Y., and Cheadle, L. 2021.

Front. Immunol. 12:703527.

Microglia and Fn14 regulate transcription and chromatin accessibility in developing neurons.

Ferro, A., Vrudhula, U., Auguste, Y., Cheadle, L. 2021.

Preprint.

Sensory experience engages microglia to shape neural connectivity through a non-phagocytic mechanism.

Cheadle, L., Rivera, A.S., Phelps, J.S., Ennis, K.A., Stevens, B., Burkly, L.C., Lee, W-C.A., and Greenberg, M.E. 2020.

Neuron 108(3):451-468.

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling.

Gunner, G., Cheadle, L.*, Johnson, K.*, Ayata, P., Badimon, A., Mondo, E., Nagy, A., Liu, L., Bemiller, S.M., Kim, K-W., Lira, S.A., Lamb, B.T., Tapper, A.R., Ransohoff, R.M., Greenberg, M.E., Schaefer, A., and Schafer, D.P. 2019.

Nature Neuroscience 22(7):1075-1088. *These authors contributed equally.

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement.

Cheadle, L.*, Tzeng, C.P.*, Kalish, B.T., Harmin, D.A., Rivera, S., Ling, E., Nagy, M.A., Hrvatin, S., Hu, L., Stroud, H., Burkly, L., Chen, C., and Greenberg, M.E. 2018.

Neuron 99(3):525-539. *These authors contributed equally.

Single-cell analysis of experience-dependent transcriptomic states in mouse visual cortex.

Hrvatin, S.*, Hochbaum, D.R.*, Nagy, M.A.*, Cicconet, M., Robertson, K., Cheadle, L., Zilionis, R., Ratner, A., Borges-Monroy, R., Klein, A.M., Sabatini, B.L., and Greenberg, M.E. 2018.

Nature Neuroscience 21(1):120-129.

Single-cell transcriptomics of the developing lateral geniculate nucleus reveals insights into circuit assembly and refinement.

Kalish, B.T.*, Cheadle, L.*, Hrvatin, S., Nagy, M.A., Rivera, S., Crow, M., Gillis, J., Kirchner, R., and Greenberg, M.E.  2018.

PNAS 115(5):E1051-E1060.  *These authors contributed equally.

Activity-dependent regulation of dendritic complexity by Semaphorin3A through Farp1.

Cheadle, L. and Biederer, T. 2014.  

The Journal of Neuroscience 34(23):7999-8009.

The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and trans-synaptic organization.

Cheadle, L. and Biederer, T. 2012.

Journal of Cell Biology 199(6): 985-1001.